Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes

Author(s): Francesco Gentili , Maria Pigini , Alessandro Piergentili , Mario Giannella .

Journal Name: Current Topics in Medicinal Chemistry

Volume 7 , Issue 2 , 2007

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Chemical and biological strategies have provided evidence for α2-receptor heterogeneity, to date classified in three different subtypes, α2A, α2B, and α2C. These are widely distributed throughout the body and mediate numerous effects; therefore, the potential therapeutic indications of agonists and antagonists are numerous. Nevertheless, the lack of subtype-selectivity of the well-known compounds represents a major limit for their use. SAR studies may help to design new and more selective drugs.

Keywords: α2-adrenoceptor agonists, α2-adrenoceptor antagonists, α2-adrenoceptor subtypes, therapeutic uses of α2-ligands, imidazoline binding sites, α2-adrenoceptor subtypes-mediated effects

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Article Details

Year: 2007
Page: [163 - 186]
Pages: 24
DOI: 10.2174/156802607779318235
Price: $58

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