Abstract
The α1 adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the α1 adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known α1 adrenoceptor agonists are α1A selective, but the discovery of highly selective α1B and α1D adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific α1 agonists as well as contributions to our understanding of agonist-receptor interactions.
Keywords: Adrenoceptor, adrenergic receptor agonist, alpha 1 agonist, norepinephrine, epinephrine
Current Topics in Medicinal Chemistry
Title: Recent Advances in the Discovery of α1-Adrenoceptor Agonists
Volume: 7 Issue: 2
Author(s): Michael J. Bishop
Affiliation:
Keywords: Adrenoceptor, adrenergic receptor agonist, alpha 1 agonist, norepinephrine, epinephrine
Abstract: The α1 adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the α1 adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known α1 adrenoceptor agonists are α1A selective, but the discovery of highly selective α1B and α1D adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific α1 agonists as well as contributions to our understanding of agonist-receptor interactions.
Export Options
About this article
Cite this article as:
Bishop J. Michael, Recent Advances in the Discovery of α1-Adrenoceptor Agonists, Current Topics in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/156802607779318217
DOI https://dx.doi.org/10.2174/156802607779318217 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Blood Pressure as a Therapeutic Target in Stroke
Current Topics in Medicinal Chemistry Recent Advancements in Diagnosis and Therapy of Liver Cirrhosis
Current Drug Targets Prodrug Strategies for Antihypertensives
Current Topics in Medicinal Chemistry 6-Oxo-Morphinane Oximes: Pharmacology, Chemistry and Analytical Application
Current Medicinal Chemistry Infection and Hemodialysis Access: An Updated Review.
Infectious Disorders - Drug Targets Some Peculiar Effects of NO-Synthase Inhibition on the Structure and Function of Cardiovascular System
Current Pharmaceutical Biotechnology A Review on Novel Ligand Targeted Delivery for Cardiovascular Disorder
Current Drug Delivery Chronic Kidney Disease and Thrombosis
Current Pediatric Reviews Proteinase-Activated Receptor-2: Physiological and Pathophysiological Roles
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Necrotizing Enterocolitis: Clinical Features, Histopathological Characteristics, and Genetic Associations
Current Pediatric Reviews Involvement of Leukotriene Pathway in the Pathogenesis of Ischemia- Reperfusion Injury and Septic and Non-Septic Shock
Current Vascular Pharmacology Milestones in Antihypertensive Drug Treatment
Current Pharmaceutical Design Nitric Oxide in Atherosclerosis
Mini-Reviews in Medicinal Chemistry Small Molecules as Anti-TNF Drugs
Current Medicinal Chemistry Potential Strategies for Minimizing Mechanism-Based Inhibition of Cytochrome P450 3A4
Current Pharmaceutical Design Monoclonal Antibodies: A New Era in the Treatment of Non-Hodgkins Lymphoma
Current Pharmaceutical Biotechnology Epigenetic Drugs in Cognitive Disorders
Current Pharmaceutical Design Cardiovascular and Metabolic Effects of Ghrelin
Current Diabetes Reviews Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update
CNS & Neurological Disorders - Drug Targets Pathophysiological Roles of Renin-Angiotensin System on Erythropoietic Action
Current Hypertension Reviews