BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury
Andrew P. Levy.
Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.
Keywords: Diabetes, Myocardial ischemia-reperfusion, Oxidative stress, BXT-51072
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