Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Author(s): Roy Asaf, Shany Blum, Rachel Miller-Lotan, Andrew P. Levy.

Abstract:

Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.

Keywords: Diabetes, Myocardial ischemia-reperfusion, Oxidative stress, BXT-51072

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [160 - 162]
Pages: 3
DOI: 10.2174/157018007779422479
Price: $58