Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines
Luiz Everson da Silva,
Antonio Carlos Joussef,
Leticia Kramer Pacheco,
Danielle Bibas Legat Albino,
Anita Mauricio Camilo Duarte,
Ricardo Andrade Rebelo.
The leishmanicidal and trypanocidal activities of chlorinated 1,7- and 1,8-naphthyridines were evaluated against cultured of L. amazonensis promastigote and T. cruzi epimastigote forms. Active compounds were also tested against blood trypomastigotes and their toxicity to Vero cells. Among the compounds evaluated 10 was the most active against L. amazonensis promastigotes and T. cruzi epimastigotes, IC50= 8.6 μM and IC50 =20.4 μM, respectively.
Keywords: Chloronaphthyridines, Antiparasitic, Trypanocidal and Leishmanicidal activities
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