Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions
Mauro Vieira De Almeida,
Marcus Vinicius de Nora Souza,
Nadia Rezende Barbosa,
Frederico Pittella Silva,
Giovanni Wilson Amarante,
Sílvia Helena Cardoso.
A series of C-2 and C-6 substituted pyridines was synthesized and evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Most of compounds exhibited a wide range of modest in vitro activity against the tested microorganisms.
Keywords: Substituted pyridines, Amide, Antimicrobial activity, Synthesis
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