Non-Covalent Binding of Disodium Disuccinate Astaxanthin to the Catalytic Site of Phosphodiesterase 5A: A Molecular Modeling Study
Samuel F. Lockwood.
Phosphodiesterases are clinical targets for congestive heart failure, erectile dysfunction and inflammation. Intake of carotenoids decreases the risk of cardiovascular and inflammatory diseases. Therefore, phosphodiesterase binding of the carotenoid derivative disodium disuccinate astaxanthin (Cardax) was investigated using molecular modeling methods. Cardax was predicted to bind to PDE5A at the catalytic site.
Keywords: Astaxanthin, Cardax, Carotenoids, Disodium disuccinate astaxanthin, Docking, Phosphodiesterase 5A
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