Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study

Author(s): Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto, Stefano Moro.

Abstract:

3D-QSAR methodologies represent a useful, widespread tool in drug discovery and optimisation. Here we introduce an alternative QSAR tool for model generation: the non-linear Response Surface Analysis, that finds at present great application in Design of Experiment for optimizing drug production processes. Binding affinity estimation of human A3 adenosine receptor antagonists is considered as key study.

Keywords: 3D-QSAR, Response Surface Analysis, Adenosine receptors

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [122 - 127]
Pages: 6
DOI: 10.2174/157018007779422460
Price: $58