Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells

Author(s): Chandrashekhar Chittimalla, Deniz Dalkara, Guy Zuber.

Abstract:

We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.

Keywords: Gene delivery, Cationic polymer, Transfection

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [92 - 98]
Pages: 7
DOI: 10.2174/157018007779422569
Price: $58