Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells
We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.
Keywords: Gene delivery, Cationic polymer, Transfection
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