Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis

Author(s): Boris A.M. Pastorino, Christophe N. Peyrefitte, Marc Grandadam, Regine Lebrun, Danielle Moinier, Dominique Rolland, Hugues J. Tolou, Mael Bessaud.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 1 , 2007

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Abstract:

We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.

Keywords: Altered specificity, autoproteolysis, flavivirin, NS3, trypsin-like serine protease

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2007
Page: [79 - 82]
Pages: 4
DOI: 10.2174/092986607779117146

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