Stability of Synthetic Exendin-4 in Human Plasma In Vitro

Author(s): Jie Chen, Ling Yu, Liping Wang, Xuexun Fang, Li Li, Wei Li.

Journal Name:Protein & Peptide Letters

Volume 14 , Issue 1 , 2007

Abstract:

Sites of exendin-4 that that are relatively susceptible to degradation in plasma were identified with the aim of providing information for designing new exendin-4 analogues. The stability of exendin-4 in human plasma was evaluated in vitro. The results showed that the peptide was slowly degraded with a half-life of 9.57 h and the principal cleavage sites are between Thr5 and Phe6, Phe6 and Thr7, and Thr7 and Ser8 of the N-terminus region of exendin-4.

Keywords: Synthetic exendin-4, Glucagon-like peptide, Stability, Dipeptidyl peptidase-IV(DPP- V)

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2007
Page: [19 - 25]
Pages: 7
DOI: 10.2174/092986607779117272