Abstract
This mini-review will provide an overview on the recent design principles and structure-activity-relationship of β-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRβ-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRα.
Keywords: Nuclear hormone receptors, thyroid hormones receptors, thyroid hormones agonists, X-ray, metabolic rate, cholesterol, heart rate, structure-activity-relationship (SAR), beta-selective
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor
Volume: 7 Issue: 1
Author(s): J. Malm, G. J. Grover and M. Farnegardh
Affiliation:
Keywords: Nuclear hormone receptors, thyroid hormones receptors, thyroid hormones agonists, X-ray, metabolic rate, cholesterol, heart rate, structure-activity-relationship (SAR), beta-selective
Abstract: This mini-review will provide an overview on the recent design principles and structure-activity-relationship of β-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRβ-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRα.
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Cite this article as:
Malm J., Grover J. G. and Farnegardh M., Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor, Mini-Reviews in Medicinal Chemistry 2007; 7 (1) . https://dx.doi.org/10.2174/138955707779317885
DOI https://dx.doi.org/10.2174/138955707779317885 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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