Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor

Author(s): J. Malm, G. J. Grover, M. Farnegardh.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 1 , 2007

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Abstract:

This mini-review will provide an overview on the recent design principles and structure-activity-relationship of β-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRβ-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRα.

Keywords: Nuclear hormone receptors, thyroid hormones receptors, thyroid hormones agonists, X-ray, metabolic rate, cholesterol, heart rate, structure-activity-relationship (SAR), beta-selective

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2007
Page: [79 - 86]
Pages: 8
DOI: 10.2174/138955707779317885

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