Hypothalamic Neuropeptide Systems as Targets for Potential Anti-Obesity Drugs

Author(s): E. Dozio, M. Ruscica, M. Motta, P. Magni.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 1 , 2007

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Abstract:

Food intake and energy homeostasis are controlled by peripheral humoral signals, afferent neuronal pathways to the brain and central signals, represented, in particular, by neuropeptides. This review reports the status of development of novel compounds targeting some hypothalamic neuropeptide systems which are currently viewed as potential targets to treat obesity.

Keywords: NPY, AgRP, MCH, orexins, galanin, POMC, CART, CRH

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2007
Page: [11 - 19]
Pages: 9
DOI: 10.2174/138955707779317894

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