Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Author(s): Andre Gustavo Tempone , Marcia de Souza Carvalho Melhem , Frederico Oliveira Prado , Gabriela Motoie , Roberto Mitsuyoshi Hiramoto , Marta Maria Antoniazzi , Celio Fernando Baptista Haddad , Carlos Jared .

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 1 , 2007

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Abstract:

The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.

Keywords: Peptides, Secretions, Amphibians, Leishmania, Trypanosoma, Antimicrobial

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [67 - 73]
Pages: 7
DOI: 10.2174/157018007778992856

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