Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Title: Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Volume: 4 Issue: 1

Author(s): Andre Gustavo Tempone, Marcia de Souza Carvalho Melhem, Frederico Oliveira Prado, Gabriela Motoie, Roberto Mitsuyoshi Hiramoto, Marta Maria Antoniazzi, Celio Fernando Baptista Haddad and Carlos Jared

Affiliation:

Keywords: Peptides, Secretions, Amphibians, Leishmania, Trypanosoma, Antimicrobial

Abstract: The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.

Cite this article as:

Gustavo Tempone Andre, de Souza Carvalho Melhem Marcia, Oliveira Prado Frederico, Motoie Gabriela, Mitsuyoshi Hiramoto Roberto, Maria Antoniazzi Marta, Fernando Baptista Haddad Celio and Jared Carlos, Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds, Letters in Drug Design & Discovery 2007; 4 (1) . https://dx.doi.org/10.2174/157018007778992856