Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Author(s): Andre Gustavo Tempone, Marcia de Souza Carvalho Melhem, Frederico Oliveira Prado, Gabriela Motoie, Roberto Mitsuyoshi Hiramoto, Marta Maria Antoniazzi, Celio Fernando Baptista Haddad, Carlos Jared.

Abstract:

The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.

Keywords: Peptides, Secretions, Amphibians, Leishmania, Trypanosoma, Antimicrobial

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [67 - 73]
Pages: 7
DOI: 10.2174/157018007778992856