Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

Back

Stem Cell Migration: A Quintessential Stepping Stone to Successful Therapy

Author(s): Corinna Weidt, Bernd Niggemann, Benjamin Kasenda, Theodore L. Drell, Kurt S. Zanker, Thomas Dittmar, Theodore L. Drell, Kurt S. Zanker.

Abstract:

Migration is an innate and fundamental cellular function that enables hematopoietic stem cells (HSCs) and endothelial progenitors (EPCs) to leave the bone marrow, relocate to distant tissue, and to return to the bone marrow. An increasing number of studies demonstrate the widening scope of the therapeutic potential of both HSCs and endothelial cells. Therapeutic success however not only relies upon their ability to repair damaged tissue, but is also fundamentally dependent on the migration to these areas. Extensive in vivo and in vitro research efforts have shown that the most significant effects seen on HSC migration are initiated by the chemokine SDF-1. In this review we will elucidate the many cellular and systemic factors of HSC and EPC cell migration and their modi operandi.

Keywords: Hematopoietic stem cell migration, homing, mobilization

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 2
ISSUE: 1
Year: 2007
Page: [89 - 103]
Pages: 15
DOI: 10.2174/157488807779317008