The Role of Stroma in Hematopoiesis and Dendritic Cell Development

Title: The Role of Stroma in Hematopoiesis and Dendritic Cell Development

Volume: 2 Issue: 1

Author(s): Genevieve Despars, Jonathan Tan, Pravin Periasamy, Helen C. O'Neill and Helen C. O'Neill

Affiliation:

Keywords: Niche, endothelial cells, hematopoiesis, dendritic cells

Abstract: Development of the immune system is depicted as a hierarchical process of differentiation from hematopoietic stem cells (HSC) to lineage-committed precursors, which further develop into mature immune cells. In the case of dendritic cell (DC) development, this linear precursor-progeny approach has led to a confused picture of relationships between various subsets of DC identifiable in vivo. A possible reconciliation of the diversity of DC precursors and DC subsets in vivo encompasses the role of the microenvironment in DC hematopoiesis. We propose here that various niches for DC hematopoiesis within lymphoid organs could account for the diversity of DC in vivo. A tridimensional space consisting of stromal cells which produce a range of membrane-bound and secreted molecules providing signals to DC progenitors would define these niches

Cite this article as:

Despars Genevieve, Tan Jonathan, Periasamy Pravin, O'Neill C. Helen and C. O'Neill Helen, The Role of Stroma in Hematopoiesis and Dendritic Cell Development, Current Stem Cell Research & Therapy 2007; 2 (1) . https://dx.doi.org/10.2174/157488807779317017