Letters in Organic Chemistry

Miguel Yus  
Universidad de Alicante Apdo
Alicante
Spain

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Convenient Synthesis of α-Amino Acid-Derived Cyclic Amides for Use as Building Blocks for Protease Inhibitors

Author(s): Maxim E. Sergeev, Tatiana L. Voyushina.

Abstract:

An efficient and straightforward approach towards the synthesis of a-amino acid-derived cyclic amides was developed. A series of cyclic amides of various natural amino acids were obtained in excellent yields under mild conditions. The obtained compounds could be efficiently used as ligands for affinity chromatography of enzymes.

Keywords: Amino acids, amides, enzymes, inhibitors, affinity chromatography

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Article Details

VOLUME: 3
ISSUE: 11
Year: 2006
Page: [857 - 860]
Pages: 4
DOI: 10.2174/157017806779117102
Price: $58