An Approach to Preparation of α-Hydroxyl Cyclobutanones from 1, 2-Bis(trimethylsiloxy)cyclobutene Catalyzed by MgI2 Etherate

Author(s): Xingxian Zhang.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 10 , 2006

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We describe an efficient and practical preparation of α-hydroxyl cyclobutanones from 1,2- Bis(trimethylsiloxy)cyclobutene (BTCB) with aromatic aldehydes, α,β-unsaturated aldehydes and their parent acetals catalyzed by 1-5 mol% of MgI2 etherate (MgI2•(OEt2)n) in dichloromethane under mild reaction conditions in good yields.

Keywords: α-Hydroxyl cyclobutanone, aldehyde, acetal, 1,2-bis(trimethylsiloxy)cyclobutene, MgI2 etherate

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Article Details

Year: 2006
Page: [749 - 752]
Pages: 4
DOI: 10.2174/157017806779025988
Price: $58

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