An Asymmetric Synthesis of the β-Hydroxy Acid Segment of Hapalosin (EXPERIMENTAL)

Author(s): Anubha Sharma, Siddharth Roy, Dibakar Goswami, Angshuman Chattopadhyay, Subrata Chattopadhyay.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 10 , 2006

Abstract:

A facile synthesis of the title compound has been developed starting from the crotylated product of (R)-cyclohexylideneglyceraldehyde (2). The key features of the synthesis were stereochemical control of the crotylation by alteration of reaction conditions, operational simplicity and the use of inexpensive compounds/reagents.

Keywords: Asymmetric synthesis, (R)-cyclohexylideneglyceraldehyde, hapalosin, β-hydroxy acid

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Article Details

VOLUME: 3
ISSUE: 10
Year: 2006
Page: [741 - 743]
Pages: 3
DOI: 10.2174/157017806779025997
Price: $58