Computer Simulations of Alzheimers Amyloid β-Protein Folding and Assembly

Author(s): Brigita Urbanc, Luis Cruz, David B. Teplow, H. Eugene Stanley.

Journal Name:Current Alzheimer Research

Volume 3 , Issue 5 , 2006

Abstract:

Pathological folding and aggregation of the amyloid β-protein (Aβ) are widely perceived as central to understanding Alzheimers disease (AD) at the molecular level. Experimental approaches to study Aβ self-assembly are limited, because most relevant aggregates are quasi-stable and inhomogeneous. In contrast, simulations can provide significant insights into the problem, including specific sites in the molecule that would be attractive for drug targeting and details of the assembly pathways leading to the production of toxic assemblies. Here we review computer simulation approaches to understanding the structural biology of Aβ. We discuss the ways in which these simulations help guide experimental work, and in turn, how experimental results guide the development of theoretical and simulation approaches that may be of general utility in understanding pathologic protein folding and assembly.

Keywords: Alzheimer's disease, amyloid β-protein, computer simulations, coarse-grained protein model, protein folding, oligomer formation, fibril formation

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Article Details

VOLUME: 3
ISSUE: 5
Year: 2006
Page: [493 - 504]
Pages: 12
DOI: 10.2174/156720506779025170
Price: $58