Current Status of Clinical Trials for Glioblastoma

Author(s): Michael L. Salgaller, Linda M. Liau.

Journal Name: Reviews on Recent Clinical Trials

Volume 1 , Issue 3 , 2006

Become EABM
Become Reviewer

Abstract:

Glioblastoma, the most highly aggressive and lethal form of brain cancer, has been a particular challenge to treat in terms of improving a patients quality of life and outcome. Each of the current treatment options is limited due to factors intrinsic to the tumors biology and the special microenvironment of its location within the brain. Surgical resection is limited by the non-circumscribed borders that can be detected. Radiation therapy has to contend with neurotoxicity to adjacent normal tissues. Chemotherapy is constrained by the blood-brain barrier, which is a very real constraint of systemic therapy - producing minimal benefit with substantial toxicity in order to administer therapeutic dosages. In part, such hurdles explain the reasons why survival has changed little over many decades of research in this field. The newest generation of treatments includes more effective cytotoxic agents, so-called targeted compounds, and biologics/immunotherapeutics. This article summarizes the preclinical proof-of-concept research and human studies involving some of the agents creating the most positive buzz in the medical community. The advantages and limitations of each are described.

Keywords: Glioma, Cancer, Chemotherapy, Radiotherapy, Vaccine, Antibody

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 1
ISSUE: 3
Year: 2006
Page: [265 - 281]
Pages: 17
DOI: 10.2174/157488706778250140
Price: $58

Article Metrics

PDF: 3