A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose

Author(s): Gang-Liang Huang, Xiang Liu, Hou-Cheng Zhang, Peng-George Wang.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 9 , 2006

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Mannose is selectively converted into mannose-1-phosphate (Man-1-P, 1) without protection of the other hydroxyl groups by phosphorylation of the anomeric hydroxyl in dry tetrahydrofuran (THF) containing phosphoric acid. Compound 1 is activated with GTP and recombinant GDP-mannose pyrophosphorylase (GDPMan PP) to give GDP-Man 2.

Keywords: Man-1-P, GDP-Man, chemo-enzymatic synthesis, two-step

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Article Details

Year: 2006
Page: [668 - 669]
Pages: 2
DOI: 10.2174/157017806778700015
Price: $65

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