A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose

Title: A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose

Volume: 3 Issue: 9

Author(s): Gang-Liang Huang, Xiang Liu, Hou-Cheng Zhang and Peng-George Wang

Affiliation:

Keywords: Man-1-P, GDP-Man, chemo-enzymatic synthesis, two-step

Abstract: Mannose is selectively converted into mannose-1-phosphate (Man-1-P, 1) without protection of the other hydroxyl groups by phosphorylation of the anomeric hydroxyl in dry tetrahydrofuran (THF) containing phosphoric acid. Compound 1 is activated with GTP and recombinant GDP-mannose pyrophosphorylase (GDPMan PP) to give GDP-Man 2.

Cite this article as:

Huang Gang-Liang, Liu Xiang, Zhang Hou-Cheng and Wang Peng-George, A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose, Letters in Organic Chemistry 2006; 3 (9) . https://dx.doi.org/10.2174/157017806778700015