Novel Strategies to Delineate Matrix Metalloproteinase (MMP)-Substrate Relationships and Identify Targets to Block MMP Activity

Author(s): M. L. Lindsey.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 11 , 2006

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Abstract:

Adverse extracellular matrix (ECM) remodeling contributes to fibrotic disorders in the kidney, lung, and heart. Matrix metalloproteinases (MMPs) are key enzymes regulating ECM turnover, and MMP inhibition attenuates remodeling. Recent technological developments allow MMP-substrate relationships to be identified and explored as novel therapeutic targets. This review summarizes current and novel strategies to block MMP activity.

Keywords: Matrix metalloproteinases, extracellular matrix, MMP inhibitors, mechanism-based inhibition, proteomics, remodeling, fibrosis

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Article Details

VOLUME: 6
ISSUE: 11
Year: 2006
Page: [1243 - 1248]
Pages: 6
DOI: 10.2174/138955706778742777
Price: $58

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