Inhibition of Hypusine Biosynthesis in Plasmodium: A Possible, New Strategy in Prevention and Therapy of Malaria

Author(s): A. Kaiser, D. Ulmer, T. Goebel, U. Holzgrabe, M. Saeftel, A. Hoerauf.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 11 , 2006

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Abstract:

The increasing drug resistance of malaria parasites against chemotherapeutics enforces new strategies in finding new drugs. Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A).

Keywords: Hypusine, dipyridyl-piperidone carbonic esters, antiplasmodial, initiation factor eIF-5A, deoxyhypusine synthase (DHS)

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Article Details

VOLUME: 6
ISSUE: 11
Year: 2006
Page: [1231 - 1241]
Pages: 11
DOI: 10.2174/138955706778742795
Price: $58

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