Abstract
Nitrofurantoin is an antimicrobial agent that is commonly used for the treatment of recurrent urinary tract infection. Nitrofurantoin pulmonary toxicity can present as acute, subacute, or chronic respiratory disease. Common manifestations are dry cough, chest pain, dyspnea, and hypoxemia. Skin rash, arthralgia, and abnormal transaminases are occasionally present. Chest imaging shows patchy infiltrates and fibrosis. Treatment includes discontinuing the medication. Although the role of corticosteroids has not been well described, patients with respiratory symptoms or hypoxemia may benefit from a trial of corticosteroid therapy.
Keywords: Nitrofurantoin, drug-induced lung toxicity, organizing pneumonia, pneumonitis
Current Respiratory Medicine Reviews
Title: Nitrofurantoin Pulmonary Toxicity: A Brief Review
Volume: 2 Issue: 4
Author(s): Bobbak Vahid and Bernadette M.M. Wildemore
Affiliation:
Keywords: Nitrofurantoin, drug-induced lung toxicity, organizing pneumonia, pneumonitis
Abstract: Nitrofurantoin is an antimicrobial agent that is commonly used for the treatment of recurrent urinary tract infection. Nitrofurantoin pulmonary toxicity can present as acute, subacute, or chronic respiratory disease. Common manifestations are dry cough, chest pain, dyspnea, and hypoxemia. Skin rash, arthralgia, and abnormal transaminases are occasionally present. Chest imaging shows patchy infiltrates and fibrosis. Treatment includes discontinuing the medication. Although the role of corticosteroids has not been well described, patients with respiratory symptoms or hypoxemia may benefit from a trial of corticosteroid therapy.
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Cite this article as:
Vahid Bobbak and Wildemore M.M. Bernadette, Nitrofurantoin Pulmonary Toxicity: A Brief Review, Current Respiratory Medicine Reviews 2006; 2 (4) . https://dx.doi.org/10.2174/157339806778777276
DOI https://dx.doi.org/10.2174/157339806778777276 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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