Synthesis and Biochemical Evaluation of a Range of Non-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of the Enzyme Complex 17α -Hydroxylase/17,20-Lyase (P45017α)

Author(s): Caroline P. Owen, Chirag H. Patel, Sachin Dhanani, Sabbir Ahmed.

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 10 , 2006

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We report the synthesis and evaluation of a range of triazole-based inhibitors of the two components of 17α-hydroxylase/17,20-lyase (P45017α). The results show that the compounds were poor inhibitors of 17α- OHase in comparison to lyase; they are therefore good lead compounds in the search for selective inhibitors of P45017α.

Keywords: 17α-Hydroxylase, 17, 20-Lyase, P45017α, Synthesis, Evaluation, Triazole

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Article Details

Year: 2006
Page: [761 - 765]
Pages: 5
DOI: 10.2174/157018006778631857
Price: $58