Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B

Author(s): Ana Rueda, Alejandro Losada, Rogelio Fernandez, Carlos Cabanas, Luis F. Garcia- Fernandez, Fernando Reyes, Carmen Cuevas.

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 10 , 2006

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The isolation, structural characterization and cytotoxic properties of three new (1-3) and three known (4-6) gracilins, obtained from the sponge Spongionella pulchella is described. Gracilin B (4) exhibited selective, broad spectrum inhibition of integrin-mediated cell adhesion to a variety of physiological substrates.

Keywords: Sponge metabolites, Gracilin, Spongionella pulchella, Anticancer agent, Integrin, Adhesion inhibitor

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Article Details

Year: 2006
Page: [753 - 760]
Pages: 8
DOI: 10.2174/157018006778631875
Price: $65

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