Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B
Luis F. Garcia- Fernandez,
The isolation, structural characterization and cytotoxic properties of three new (1-3) and three known (4-6) gracilins, obtained from the sponge Spongionella pulchella is described. Gracilin B (4) exhibited selective, broad spectrum inhibition of integrin-mediated cell adhesion to a variety of physiological substrates.
Keywords: Sponge metabolites, Gracilin, Spongionella pulchella, Anticancer agent, Integrin, Adhesion inhibitor
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