Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B

Title: Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B

Volume: 3 Issue: 10

Author(s): Ana Rueda, Alejandro Losada, Rogelio Fernandez, Carlos Cabanas, Luis F. Garcia- Fernandez, Fernando Reyes and Carmen Cuevas

Affiliation:

Keywords: Sponge metabolites, Gracilin, Spongionella pulchella, Anticancer agent, Integrin, Adhesion inhibitor

Abstract: The isolation, structural characterization and cytotoxic properties of three new (1-3) and three known (4-6) gracilins, obtained from the sponge Spongionella pulchella is described. Gracilin B (4) exhibited selective, broad spectrum inhibition of integrin-mediated cell adhesion to a variety of physiological substrates.

Cite this article as:

Rueda Ana, Losada Alejandro, Fernandez Rogelio, Cabanas Carlos, F. Garcia- Fernandez Luis, Reyes Fernando and Cuevas Carmen, Gracilins G-I, Cytotoxic Bisnorditerpenes from Spongionella pulchella, and the Anti-Adhesive Properties of Gracilin B, Letters in Drug Design & Discovery 2006; 3 (10) . https://dx.doi.org/10.2174/157018006778631875