Oleoylethanolamide: a Molecular Cross-Talk with Leptin in Feeding Behaviour Regulation

Author(s): Buenaventura Brito, Rafael Castro, Antonio Cabrera de Leon.

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 10 , 2006

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Oleoylethanolamide is an endogenous lipid mediator that reduces food intake and decreases body weight gain in rodents. As in leptin, oleoylethanolamide has a central and peripheral anorexic effect. In this article, we describe common potential targets, suggesting a molecular cross-talk between leptin and oleoylethanolamide which may regulate feeding behaviour.

Keywords: Oleoylethanolamide (OEA), Leptin, Obesity, Anorexigenic, Feeding behaviour, Anti-obesity effects, Rats

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Article Details

Year: 2006
Page: [741 - 746]
Pages: 6
DOI: 10.2174/157018006778631901
Price: $58