Mini-Reviews in Medicinal Chemistry

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Preservation Solutions for Solid Organ Transplantation

Author(s): C. H. Wilson, N. R. Brook, D. Talbot.

Abstract:

Solid organ transplantation was one of the greatest medical advances of the 20th century. Current preservation technology falls short of maintaining organs ex vivo in perpetuity. This review examines the biochemical basis of organ degradation in response to ischaemia, preservation solution composition and potential future organ preservation technology.

Keywords: Organ transplantation, preservation solutions, machine perfusion preservation, hypothermia

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Article Details

VOLUME: 6
ISSUE: 10
Year: 2006
Page: [1081 - 1090]
Pages: 10
DOI: 10.2174/138955706778560148
Price: $58