Intracellular Amyloid β-Protein and Its Associated Molecules in the Pathogenesis of Alzheimers Disease

Author(s): Yasumasa Ohyagi, Takeshi Tabira.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 10 , 2006

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Abstract:

Amyloid β-protein (Aβ) plays a pivotal role in Alzheimers disease (AD). Therapeutic strategies inhibiting Aβ aggregation and promoting extracellular Aβ removal are currently advocated. Here, we review recent literature on intracellular Aβ, especially intranuclear Aβ, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Aβ-related pathogenesis.

Keywords: Alzheimer's disease, amyloid β-protein, intracellular, intranuclear, Aβ-related Death Inducing Protein, p53, promoter, apoptosis, amyloid -protein, related Death Inducing Protein

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Article Details

VOLUME: 6
ISSUE: 10
Year: 2006
Page: [1075 - 1080]
Pages: 6
DOI: 10.2174/138955706778560175
Price: $58