Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes

Author(s): Lassi Jaakkola and Jari Hovinen

Volume 3, Issue 8, 2006

Page: [643 - 647] Pages: 5

DOI: 10.2174/157017806778559491

Price: $65

Abstract

3-(4-Iodophenoxy)-tris(2-nitrobenzenesulfonyl)-1,4,7-triazacyclodecane (5a) was synthesized by a Mitsunobu reaction between pernosylated diethylenetriamine (4a) and 1,3-bis(trityloxy)propan-2-ol (2). 5a served as a key intermediate in the preparation of MRI contrast agents allowing biomolecule labeling both in solution and on solid phase.

Keywords: MRI, labeling, azamacrocycle, Mitsunobu reaction

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy