Versatile Synthesis of MRI Contrast Agents Based on Carbon-Substituted Triazacycloalkanes

Author(s): Lassi Jaakkola, Jari Hovinen.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 8 , 2006

Become EABM
Become Reviewer

Abstract:

3-(4-Iodophenoxy)-tris(2-nitrobenzenesulfonyl)-1,4,7-triazacyclodecane (5a) was synthesized by a Mitsunobu reaction between pernosylated diethylenetriamine (4a) and 1,3-bis(trityloxy)propan-2-ol (2). 5a served as a key intermediate in the preparation of MRI contrast agents allowing biomolecule labeling both in solution and on solid phase.

Keywords: MRI, labeling, azamacrocycle, Mitsunobu reaction

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 3
ISSUE: 8
Year: 2006
Page: [643 - 647]
Pages: 5
DOI: 10.2174/157017806778559491
Price: $58

Article Metrics

PDF: 1