A Practical Synthesis of Thio-Bisphosphonic Acids For the Treatment of Arthritis, Based on the Chemistry of Tetraethyl Methylene-1,1- Bisphosphonate

Author(s): Wafaa M. Abdou, Maha D. Khidre, Ashraf A. Sediek.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 8 , 2006

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Abstract:

The synthesis of novel S-bisphosphonates (S-BPs) by two different approaches is described. Hydrolysis of the resulted BPs with conc. HCl afforded the corresponding thio-bisphosphonic acids. The properties of these compounds in the rat adjuvant model of arthritis, and the synthetic routes to these and related compounds are detailed.

Keywords: Cyclic-and acyclic cis-disulfides, Shiff-bases, Sulfur-containing bisphosphonic acids, Arthritis/Inflammatory

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Article Details

VOLUME: 3
ISSUE: 8
Year: 2006
Page: [634 - 639]
Pages: 6
DOI: 10.2174/157017806778559536
Price: $58

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