The synthesis of novel S-bisphosphonates (S-BPs) by two different approaches is described. Hydrolysis of the resulted BPs with conc. HCl afforded the corresponding thio-bisphosphonic acids. The properties of these compounds in the rat adjuvant model of arthritis, and the synthetic routes to these and related compounds are detailed.
Keywords: Cyclic-and acyclic cis-disulfides, Shiff-bases, Sulfur-containing bisphosphonic acids, Arthritis/Inflammatory
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