The enantioselective bioreduction of alpha-substituted-acetophenones 1,2 was carried out with cells of fungi to give the corresponding chiral alcohols in good yield and high enantioselectivity (up to 99%). The chiral alcohols 3 and 4 obtained by this methodology are important intermediates for the asymmetric syntheses of chiral drugs. The enantioselectivity presented by several fungal strains was anti-Prelog.
Keywords: Bioreduction, hydrolysis, ketone, chiral alcohol, fungus
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