Application of Bioreduction by Microorganisms in the Enantioselective Synthesis of Alpha-Substituted-1-Phenylethanols

Author(s): Leandro H. Andrade, Roberta Polak, Andre L. M. Porto, Iracema H. Schoenlein-Crusius, Joao V. Comasseto.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 8 , 2006

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Abstract:

The enantioselective bioreduction of alpha-substituted-acetophenones 1,2 was carried out with cells of fungi to give the corresponding chiral alcohols in good yield and high enantioselectivity (up to 99%). The chiral alcohols 3 and 4 obtained by this methodology are important intermediates for the asymmetric syntheses of chiral drugs. The enantioselectivity presented by several fungal strains was anti-Prelog.

Keywords: Bioreduction, hydrolysis, ketone, chiral alcohol, fungus

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Article Details

VOLUME: 3
ISSUE: 8
Year: 2006
Page: [613 - 618]
Pages: 6
DOI: 10.2174/157017806778559509
Price: $58

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