Pharmacophore Models for Metabotropic 5-HT Receptor Ligands

Author(s): Andrzej J. Bojarski.

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 18 , 2006

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Abstract:

An overview of pharmacophore models, developed for different subtypes of serotonin receptors belonging to the GPCR family, is presented. Starting with early models for 5-HT1A and 5-HT2 receptor ligands, and ending with the latest ones for 5-HT6- and 5-HT7 receptors, as many as fifty others are briefly summarized. No models have been developed for 5-HT1F-, 5-HT2B- and 5-HT5B receptor ligands, and in the case of 5-HT1E- and 5-HT5ARs only single pilot studies with non-selective tryptamine derivatives are reported. For all the other subtypes of 5-HTRs, various pharmacophore hypotheses - either qualitative and/or quantitative - are characterized by sets of ligands used for their generation, a templates for alignment, the computational methods applied and, eventually, interfeature distances and/or statistical results - if available.

Keywords: 5-HT1 receptors, 5-HT2 receptors, 5-HT4 receptors, 5-HT6 receptors, 5-HT7 receptors, pharmacophore models, 3-D QSAR

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Article Details

VOLUME: 6
ISSUE: 18
Year: 2006
Page: [2005 - 2026]
Pages: 22
DOI: 10.2174/156802606778522186
Price: $58

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