Selective Agents for Serotonin2C (5-HT2C) Receptor

Author(s): Enza Lacivita, Marcello Leopoldo.

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 18 , 2006

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The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.

Keywords: CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine

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Article Details

Year: 2006
Page: [1927 - 1970]
Pages: 44
DOI: 10.2174/156802606778522168
Price: $58

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