Eicosanoids as Therapeutic Targets in Asthma

Author(s): P. Rastogi, J. McHowat.

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 9 , 2006

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Abstract:

Asthma is a chronic inflammatory disease of the airways associated with variable airflow obstruction and increased responsiveness to a variety of stimuli. Arachidonic acid metabolites play an important role in the pathophysiology of asthma and in this review we examine the major products of the lipoxygenase and cycloxygenase pathways, their effects on the airways and the current strategies used to target them.

Keywords: Arachidonic acid, Phospholipase A2, Lipoxygenase, Thromboxanes, Cycloxygenase

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Article Details

VOLUME: 3
ISSUE: 9
Year: 2006
Page: [668 - 674]
Pages: 7
DOI: 10.2174/157018006778341165
Price: $58