Abstract
The therapeutic efficacy of most pharmacological agents is generally established first in rodents and then in humans. To better extrapolate the effects of pharmacological agents in rodents to humans it is important to know how similar (or dissimilar) systems are between rodents and humans. This review examines the differences in the localization of the noradrenergic receptors in the hippocampus of humans and rodents. The differences in receptor localization could have major implications for the actions (or side effects) of noradrenergic agents in humans.
Keywords: Norepinephrine, Adrenoreceptors, Hippocampus, Alpha receptors, Beta receptors
Letters in Drug Design & Discovery
Title: Comparison of Noradrenergic Receptor Distribution in the Hippocampus of Rodents and Humans: Implications for Differential Drug Response
Volume: 3 Issue: 9
Author(s): Patricia Szot
Affiliation:
Keywords: Norepinephrine, Adrenoreceptors, Hippocampus, Alpha receptors, Beta receptors
Abstract: The therapeutic efficacy of most pharmacological agents is generally established first in rodents and then in humans. To better extrapolate the effects of pharmacological agents in rodents to humans it is important to know how similar (or dissimilar) systems are between rodents and humans. This review examines the differences in the localization of the noradrenergic receptors in the hippocampus of humans and rodents. The differences in receptor localization could have major implications for the actions (or side effects) of noradrenergic agents in humans.
Export Options
About this article
Cite this article as:
Szot Patricia, Comparison of Noradrenergic Receptor Distribution in the Hippocampus of Rodents and Humans: Implications for Differential Drug Response, Letters in Drug Design & Discovery 2006; 3 (9) . https://dx.doi.org/10.2174/157018006778341200
DOI https://dx.doi.org/10.2174/157018006778341200 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers