Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Comparison of Noradrenergic Receptor Distribution in the Hippocampus of Rodents and Humans: Implications for Differential Drug Response

Author(s): Patricia Szot.


The therapeutic efficacy of most pharmacological agents is generally established first in rodents and then in humans. To better extrapolate the effects of pharmacological agents in rodents to humans it is important to know how similar (or dissimilar) systems are between rodents and humans. This review examines the differences in the localization of the noradrenergic receptors in the hippocampus of humans and rodents. The differences in receptor localization could have major implications for the actions (or side effects) of noradrenergic agents in humans.

Keywords: Norepinephrine, Adrenoreceptors, Hippocampus, Alpha receptors, Beta receptors

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Article Details

Year: 2006
Page: [645 - 652]
Pages: 8
DOI: 10.2174/157018006778341200
Price: $58