Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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ABC Transporters and Isothiocyanates

Author(s): Ian Derek Kerr, Nigel Simon Simpkins.

Abstract:

Identification of naturally occurring compounds as potential anti-cancer chemotherapy drugs is a prominent research area. Simple dietary isothiocyanates have a spectrum of cellular targets including effects on ATP binding cassette (ABC) transporters, which mediate resistance to chemotherapy. Recent investigations have identified complex compounds, containing an isothiocyanate, which may be more specific inhibitors of ABC transporters.

Keywords: Isothiocyanate, ABC Transporter, Chemoprevention, Multidrug Resistance, Welwistatin

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Article Details

VOLUME: 3
ISSUE: 9
Year: 2006
Page: [607 - 621]
Pages: 15
DOI: 10.2174/157018006778341147
Price: $58