Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Glycosyl Phosphatidylinositol-Anchored Proteins and HIV Infection

Author(s): Massimo Alfano, Luca Cassetta, Guido Poli.

Abstract:

In addition to CD4 and chemokine receptors glycosyl phosphatidylinositol-anchored proteins (GPIAPs) have been involved in the regulation of the human immunodeficiency virus (HIV) life cycle. In this article we will review the mechanisms underlying the anti-HIV activities regulated by GPI-APs and their ligands. Understanding how GPI-APs finely regulate HIV infection and replication may unravel novel and complementary strategies to combat and control HIV infection.

Keywords: GPI (Glycosyl Phosphatidylinositol), GPI-AP (Glycosyl Phosphatidylinositol-Anchored Protein), HIV (Human Immunodeficiency Virus), uPA (urokinase plasminogen activator), PTXB (pertussis toxin B-oligomer)

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Article Details

VOLUME: 3
ISSUE: 9
Year: 2006
Page: [598 - 604]
Pages: 7
DOI: 10.2174/157018006778341183
Price: $58