Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis
Mark A. Lovell and William R. Markesbery
Affiliation: 135 Sanders-Brown Building,800 S. Limestone St., Lexington, KY 40536, USA.
Keywords: anti-apoptotic proteins, oxidative damage, permeability transition pore (PTP), sodium/potassium-transporting ATPase, dependent anion channel (VDAC)
Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimers disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration.
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