Abstract
Pancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development and β-cell differentiation, and functions as an activator of insulin gene transcription. MafA is a recently isolated β-cell-specific transcription factor which functions as a potent activator of insulin gene transcription. PDX-1 and MafA play crucial roles in inducing insulin-producing cells from non- β-cells and could be therapeutic targets for diabetes. On the other hand, expression and/or activities of PDX-1 and MafA in β-cells are reduced under diabetic conditions. Alteration of such transcription factors leads to suppression of insulin biosynthesis and secretion and thus explains, at least in part, the molecular mechanism for β-cell glucose toxicity.
Keywords: pancreas development, bHLH transcription factor, maturity-onset diabetes of the young (MODY), insulin gene, PDX-1-VP16 fusion protein
Current Signal Transduction Therapy
Title: PDX-1 and MafA as Potential Therapeutic Targets for Diabetes
Volume: 1 Issue: 3
Author(s): Hideaki Kaneto, Takeshi Miyatsuka and Taka-aki Matsuoka
Affiliation:
Keywords: pancreas development, bHLH transcription factor, maturity-onset diabetes of the young (MODY), insulin gene, PDX-1-VP16 fusion protein
Abstract: Pancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development and β-cell differentiation, and functions as an activator of insulin gene transcription. MafA is a recently isolated β-cell-specific transcription factor which functions as a potent activator of insulin gene transcription. PDX-1 and MafA play crucial roles in inducing insulin-producing cells from non- β-cells and could be therapeutic targets for diabetes. On the other hand, expression and/or activities of PDX-1 and MafA in β-cells are reduced under diabetic conditions. Alteration of such transcription factors leads to suppression of insulin biosynthesis and secretion and thus explains, at least in part, the molecular mechanism for β-cell glucose toxicity.
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Cite this article as:
Kaneto Hideaki, Miyatsuka Takeshi and Matsuoka Taka-aki, PDX-1 and MafA as Potential Therapeutic Targets for Diabetes, Current Signal Transduction Therapy 2006; 1 (3) . https://dx.doi.org/10.2174/157436206778226905
DOI https://dx.doi.org/10.2174/157436206778226905 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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