Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery
Iva Ivanovska, Clare N. Muhoro and Pablo M. Irusta
Pages 1033-1042 (10)
Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.
Cancer, apoptosis, IAP, Caspases, Bcl-2
Department of Human Science,Georgetown Medical Center, Georgetown University, 3700 Reservoir Road, NW, Washington DC 20057, USA.