Mini-Reviews in Medicinal Chemistry

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Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery

Author(s): Iva Ivanovska, Clare N. Muhoro, Pablo M. Irusta.

Abstract:

Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.

Keywords: Cancer, apoptosis, IAP, Caspases, Bcl-2

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Article Details

VOLUME: 6
ISSUE: 9
Page: [1033 - 1042]
Pages: 10
DOI: 10.2174/138955706778195216
Price: $58