Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Microtubules and Commuting Receptors

Author(s): M. Modriansky, J. Ulrichova, Z. Dvorak.

Abstract:

Receptors that undergo nucleo-cytoplasmic shuttling require microtubules for proper physiologic function. Is it the collapse of microtubules network or simply the arrest of cell cycle in G2/M phase that changes receptors function? The terms of disengagement and the integrity versus dynamics of the microtubules shall guide the ideal drug design.

Keywords: Cytoskeleton, Transcriptional regulation, Nuclear receptors, Drug metabolism

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Article Details

VOLUME: 3
ISSUE: 8
Year: 2006
Page: [567 - 568]
Pages: 2
DOI: 10.2174/157018006778194718
Price: $58