Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Syntheses of Disaccharide Units of Manβ (1→6)Man, Man (1→6)Manα and Glcα (1→6)Man, and Their Interactions for Concanavalin A

Author(s): Takashi Yamanoi, Hitomi Hamada, Yoshiki Oda, Kenjiro Hattori.

Abstract:

We investigated the synthesis of the disaccharide units of Manβ(1→ 6)Manα1→ OPh, Manα(1→ 6)Manα1→ OPh and Glcα(1→ 6)Manβ1→ OPh as the analogues of the α(1→6) arm of the mannotrisaccharide core in N-linked glycopeptides using the dimethylphosphinothioate method. Studies using a surface plasmon resonance optical biosensor indicated that the Manβ(1→6)Manα1→ OPh had an association constant of 1.15 104 M-1 for immobilized Concanavalin A, which almost corresponded to that of the Manα(1→ 6)Manα1→ OPh.

Keywords: Concanavalin A, β1,6-linked disaccharide, Mannodisaccharide, Association constant, Dimethylphosphinothioate, SPR

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Article Details

VOLUME: 3
ISSUE: 8
Year: 2006
Page: [547 - 549]
Pages: 3
DOI: 10.2174/157018006778194763
Price: $58