Chiral Amino-Amides as Solution Phase and Immobilized Ligands for the Catalytic Asymmetric Alkylation of Aromatic Aldehydes

Author(s): Alessandra Silvani, Alessandro Sacchetti, Daniele Passarella, Bruno Danieli, Giordano Lesma.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 6 , 2006

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Abstract:

Novel chiral amino-amide 9-keto-bispidines are investigated as ligands in the addition reaction of diethylzinc to aromatic aldehydes. The ligands are easily obtained by a single step procedure starting from commercially available products. Selected ligands were also supported onto different insoluble resins in order to test their activity as heterogeneous catalysts.

Keywords: diethylzinc, bispidine, 3,7-diazabicyclo[3.3.1]nonane, asymmetric synthesis, Chiral ligand

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2006
Page: [430 - 436]
Pages: 7
DOI: 10.2174/157017806777828529
Price: $65

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