Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide

Author(s): Ajit Chand Kunwar, Gangavaram V. M. Sharma, Anabathula Prabhakar, Sreenivas Punna.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 6 , 2006

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Abstract:

Synthesis of the C3-C10 and C13-C21 segments, having seven asymmetric centers of the marine macrolide, (-)-laulimalide is reported. The requisite stereogenic centers were generated on the chirons by the application of asymmetric reactions.

Keywords: intramolecular cyclization, chiron, stereoselective synthesis, Sharpless asymmetric epoxidation, laulimalide, Marine macrolide

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2006
Page: [447 - 454]
Pages: 8
DOI: 10.2174/157017806777828411
Price: $58

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