A Simple Synthesis of Orthogonally Protected 2,5-Diaminocyclohexanecarboxylic Acids

Author(s): Ferenc Fulop, Istvan Szatmari, Lorand Kiss.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 6 , 2006

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Abstract:

Simple and efficient methods have been developed for the synthesis of orthogonally protected 2,5- diaminocyclohexanecarboxylic acid diastereomers via the stereocontrolled transformation of 2-benzyloxycarbonylamino-4-cyclohexenecarboxylic acid to its iodolactone or epoxide.

Keywords: orthogonal protection, β-peptides, β-amino acids, Diaminocarboxylic acids

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Article Details

VOLUME: 3
ISSUE: 6
Year: 2006
Page: [463 - 467]
Pages: 5
DOI: 10.2174/157017806777828501
Price: $58

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