Microwave-Promoted Facile and Rapid Solvent-Free Synthesis Procedure for the Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and -Thiones Using ZrO2/SO42- as a Reusable Heterogeneous Catalyst

Author(s): Muthuvel R. Ezhilarasi, Ramalingam Govindaraju, Jeyaraman Thanusu, Vijayakumar Kanagarajan, Purushothaman Sureshkumar, Mannathusamy Gopalakrishnan.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 6 , 2006

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Sulfated zirconia (ZrO2/SO4 2-) solid superacid has been proved to be an efficient reusable heterogeneous catalyst for three-component one-pot cyclocondensation reaction of β-dicarbonyl compounds and urea/thiourea with structurally diverse aromatic aldehydes in solvent-free conditions to furnish the corresponding 3,4-dihydropyrimidin-2(1H)-ones and -thiones in good to excellent yields both under microwave irradiation and thermal conditions.

Keywords: green chemistry, microwave irradiation, dihydropyrimidinones, sulfated zirconia, Biginelli reaction

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Article Details

Year: 2006
Page: [484 - 488]
Pages: 5
DOI: 10.2174/157017806777828493
Price: $65

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