Efficient Method for the Synthesis of Optically Pure Terminal Olefin Bearing Long Chain α-Amino Acids

Title: Efficient Method for the Synthesis of Optically Pure Terminal Olefin Bearing Long Chain α-Amino Acids

Volume: 3 Issue: 6

Author(s): Ge Li, Shu-Hui Chen, Rujian Ma, Suhan Tang, Yifeng Shi, Jingchao Dong, Zhiliu Zhang, Wei Miao and Lanqi Jia

Affiliation:

Keywords: BILN-2061, terminal olefin, long chain, optically pure α-amino acid, Synthesis

Abstract: We present herein a general method for the preparation of chiral terminal olefin bearing long chain α- amino acids via the following three-step sequence starting from (S)-N-Boc-2-pyrrolidone-5-carboxylic acid: (1) opening of the γ-lactam ring by an organometallic reagent, (2) keto reduction, and (3) ester hydrolysis.

Cite this article as:

Li Ge, Chen Shu-Hui, Ma Rujian, Tang Suhan, Shi Yifeng, Dong Jingchao, Zhang Zhiliu, Miao Wei and Jia Lanqi, Efficient Method for the Synthesis of Optically Pure Terminal Olefin Bearing Long Chain α-Amino Acids, Letters in Organic Chemistry 2006; 3 (6) . https://dx.doi.org/10.2174/157017806777828385