Efficient Method for the Synthesis of Optically Pure Terminal Olefin Bearing Long Chain α-Amino Acids

Author(s): Ge Li, Shu-Hui Chen, Rujian Ma, Suhan Tang, Yifeng Shi, Jingchao Dong, Zhiliu Zhang, Wei Miao, Lanqi Jia.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 6 , 2006

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We present herein a general method for the preparation of chiral terminal olefin bearing long chain α- amino acids via the following three-step sequence starting from (S)-N-Boc-2-pyrrolidone-5-carboxylic acid: (1) opening of the γ-lactam ring by an organometallic reagent, (2) keto reduction, and (3) ester hydrolysis.

Keywords: BILN-2061, terminal olefin, long chain, optically pure α-amino acid, Synthesis

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Article Details

Year: 2006
Page: [489 - 491]
Pages: 3
DOI: 10.2174/157017806777828385
Price: $65

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